Stimuli-responsive nanomaterials have gained increasing attention in a variety of biomedical applications such as molecular imaging, drug/gene delivery and immunotherapy. Our research group aims to create smart biopolymers and nanomedicines to amplify pathophysiological signals (pH, enzyme, and hypoxia, etc.) or therapeutic efficacy to improve the clinical outcomes.
Tumor angiogenesis and aerobic glycolysis (also known as the Warburg effect) are recognized hallmarks of cancer, which are ubiquitous in solid tumors, regardless of cancer type. We developed a series of pH-sensitive nanomedicines to achieve precise amplification of tumor acidosis (pHe) and angiogenesis signals for image-guided cancer theranostics.
Nanoparticles interacting with serum proteins, membranes, cell and organelles create a series of nanoparticle/biological interfaces. The deep understanding of the mechanisms underlying the Nano-Bio interfaces is crucial for the rational design and development of multifunctional nanomedicine for efficient and personalized therapy. Herein, we developed a hybrid fluorescent nanoreporter for the digitization of maturation of endocytic organlles, which play central role in cellular functions and drug/gene delivery.