Selected Publications

1.   Chen BL†,*, Wan FJ†, Xia HM, Pan XQ, Wang LT, Wang YQ, Yan Y, Liu JX, Tang MM, Yang Y, Qin MM, Ren JN, Zhou BS, Zhong LJ, Chen W, Han CH, Deng M, Zhang Q*, Wang YG*. Nature Materials. 2025, In press. 

2.   Chen BL, Yan Y, Yang Y, Cao G, Wang X, Wang YQ, Wan FJ, Yin QQ, Wang ZH, Li YF, Wang LT, Xu B, You FP*, Zhang Q*, Wang YG*. A pyroptosis nanotuner for cancer therapy. Nature Nanotechnology. 2022, 17, 788-798. 

3.   Yang Y, Chen BL, Wan FJ, Fu CX, Chen MF, Ma B, Zhao RY, Pan MJ, Zhang Q, Wang YG*. Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging. Nature Communications. 2025 , 16, 5770. 

4.    Liu JX†, Yan Y†, Zhang YM, Pan XQ, Xia HM, Wan FJ, Huang XY, Zhang Q, Chen BL*, Wang YG*. Lysosome-mitochondria cascade targeting nanoparticle drives robust pyroptosis for cancer immunotherapy. J. Am. Chem. Soc. 2024, 146, 34568-34582. 

5.  Pan MJ, Zhao RY, Fu CX, Tang MM, Zhou JY, Ma B, Liu JX, Yang Y, Chen BL, Zhang Q, Wang YG*. Tuning nanoparticle core composition drives orthogonal fluorescence amplification for enhanced tumour imaging. Nature Communications. 2024, 15, 7824.  

6.   Tang MM, Chen BL, Xia HM, Pan MJ, Zhao RY, Zhou JY, Yin QQ, Wan FJ, Yan Y, Fu CX, Zhong LJ, Zhang Q, Wang YG*. pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy. Nature Communications. 2023, 14, 5888. 

7.    Yan Y†, Chen BL†, Yin QQ, Wang ZH, Yang Y, Wan FJ, Wang YQ, Tang MM, Wang SL, Zhang Q, Wang YG*. Dissecting extracellular and intracellular distribution of nanoparticles and their Contribution to therapeutic response by monochromatic ratiometric imaging. Nature Communications. 2022, 13, 2004. 

8.      Zhao RY†, Fu CX†, Wang ZH, Pan MM, Ma B, Yin QQ, Chen BL, Liu JX, Xia HM, Wan FJ, Wang LT, Zhang Q, Wang YG*. A pH-responsive nanoparticle library with precise pH tunability by co-polymerization with non-ionizable monomers. Angewandte Chemie International Edition. 2022, 61, e202200152. 

9.     Yin QQ, Pan AN, Chen BL, Wang ZH, Tang MM, Yan Y, Wang YQ, Xia HM, Chen W, Du HL, Chen MF, Fu CX, Wang YN, Yuan X, Lu ZH, Zhang Q, Wang YG*. Quantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy. Nature Communications. 2021, 12, 2385. 

10.   Wang YG, Zhou KJ, Huang G, Hensley C, Huang XN, Ma XP, Zhao T, Sumer BD, DeBerardinis RJ, Gao JM*. A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Nature Materials. 2014, 13, 204-212. 

Education

• 2005.9-2008.7 Ph.D., Department of Pharmaceutics, Peking University, Beijing, China  (Advisor: Prof. Qiang Zhang)
• 2002.9-2005.7 M.Sc., Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (Advisor: Prof. Siling Wang)
• 1998.9-2002.7 B.Sc., School of Pharmacy, Shandong University, Jinan, Shandong, China

Award and Honors

• 2023     Tu Youyou Young Investigator Award
• 2022     Bayer Investigator Award
• 2022     National Natural Science Fund for Distinguished Young Scholars, NSFC
• 2019     Beijing Natural Science Fund for Distinguished Young Scholars, BJNSF
• 2017     Senofi Young Scientist Award in Bio-pharmaceuticals from Chinese Pharmaceutical Association
• 2016     National Natural Science Fund for Excellent Young Scholars, NSFC
• 2015     Young Scientist Award in Pharmaceutical Science from Chinese Pharmaceutical Association
• 2014     The Recruitment Program of Youth Experts, Peking University

Professional Career

• 2023.1-Present       Boya Distinguished Professor, School of Pharmaceutical Sciences, Peking University 
• 2021.8-2022.12      Associate Professor (with Tenure), School of Pharmaceutical Sciences, Peking University
• 2015.3-2021.7        Assistant Professor (Tenure Track), School of Pharmaceutical Sciences, Peking University
• 2010.6-2015.2        Postdoctoral Fellow, University of Texas Southwestern Medical Center (Advisor: Prof. Jinming Gao)
• 2008.7-2010.5        Postdoctoral Fellow, Institute of biophysics, Chinese Academy of Sciences (Advisor: Prof. Wei Liang)

Education

• 2005.9-2008.7         Ph.D. in Pharmaceutics, Peking University, Beijing, China (Advisor: Prof. Qiang Zhang)
• 2002.9-2005.7         M.Sc. in Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China (Advisor: Prof.  Siling Wang)
• 1998.9-2002.7         B.Sc. in Pharmacy, Shandong University, Jinan, China