Stimuli-responsive nanoparticles have gained increasing importance in variety of applications such as drug delivery, molecular imaging and immunotherapy. Our research group aims to create smart nanomedicines to amplify biological signals (pH, enzyme, and hypoxia, etc.) or therapeutic efficacy to improve the clinical outcomes. Such example includes the development of pH-sensitive nanomedicines to achieve precise amplification of tumor acidosis (pHe) and angiogenesis signals for image-guided cancer theranostics. We are also interested in the development of novel strategies to modulate the tumor microenvironment for the enhanced drug delivery and therapeutic responsiveness.
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