​THE WANG RESEARCH GROUP

School of Pharmaceutical Sciences, Peking University

Dr. Yiguang Wang

Associate Professor

Head of Department of Pharmaceutics

Peking University School of Pharmaceutical Sciences


Address:38 Xueyuan Road, Haidian District, Beijing 100191

Telephone: +86-10-82805084

Email: yiguang.wang@pku.edu.cn

Education
  • 2005.9-2008.7 Ph.D., Department of Pharmaceutics, Peking University, Beijing, China  (Advisor: Prof. Qiang Zhang)
  • 2002.9-2005.7 M.Sc., Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (Advisor: Prof. Siling Wang)
  • 1998.9-2002.7 B.Sc., School of Pharmacy, Shandong University, Jinan, Shandong, China

   

Award and Honors

  • 2019     Distinguished Young Scientist of Beijing Natural Science Foundation (BJNSF)
  • 2017     Senofi Young Scientist Award in Bio-pharmaceuticals from Chinese Pharmaceutical Association
  • 2016     Excellent Young Scientist of National Natural Science Foundation of China (NSFC)
  • 2015     Young Scientist Award in Pharmaceutical Science from Chinese Pharmaceutical Association
  • 2014     The Recruitment Program of Youth Experts, Peking University

Professional Career

  • 2021.8-Present       Associate Professor (Tenured), School of Pharmaceutical Sciences, Peking University
  • 2015.3-2021.7        Assistant Professor (Tenure Track), School of Pharmaceutical Sciences, Peking University
  • 2010.6-2015.2        Postdoctoral Fellow, University of Texas Sou​​thwestern Medical Center (Advisor: Prof. Jinming Gao)
  • 2008.7-2010.5        Postdoctoral Fellow, Institute of biophysics, Chinese Academy of Sciences (Advisor: Prof. Wei Liang)

Selected Publications

1.  Chen B, Yan Y, Yang Y, Cao G, Wang X, Wang YQ, Wan F, Yin Q, Wang Z, Li Y, Wang L, Xu B, You F*, Zhang Q*, Wang YG*. A Pyroptosis Nanotuner for Cancer Therapy. Nature Nanotechnology. 2022, DOI: 10.1038/s41565-022-01125-0. 

2.  Yan Y, Chen B, Yin Q, Wang Z, Yang Y, Wan F, Wang YQ, Tang M, Wang S, Zhang Q, Wang YG*. Dissecting Extracellular and Intracellular Distribution of Nanoparticles and Their Contribution to Therapeutic Response by Monochromatic Ratiometric Imaging. Nature Communications. 2022, 13, 2004. 

3.  Zhao R, Fu C, Wang Z, Pan M, Ma B, Yin Q, Chen B, Liu J, Xia H, Wan F, Wang L, Zhang Q, Wang YG*. A pH-Responsive Nanoparticle Library with Precise pH Tunability by Co-Polymerization with Non-Ionizable Monomers. Angewandte Chemie International Edition. 2022, 61, e202200152. (VIP paper)

4.  Xia H, Qin M, Wang Z, Wang YQ, Chen B, Wan F, Tang M, Pan X, Yang Y, Liu J, Zhao R, Zhang Q, Wang YG*. A pH-/Enzyme-Responsive Nanoparticle Selectively Targets Endosomal Toll-like Receptors to Potentiate Robust Cancer Vaccination. Nano Letters. 2022, 22, 2978-2987. 

5.  Yin Q, Pan A, Chen B, Wang Z, Tang M, Yan Y, Wang YQ, Xia H, Chen W, Du H, Chen M, Fu C, Wang YN, Yuan X, Lu Z, Zhang Q, Wang YG*. Quantitative Imaging of Intracellular Nanoparticle Exposure Enables Prediction of Nanotherapeutic Efficacy. Nature Communications. 2021, 12, 2385. 

6.  Zhang J, Rakhimbekova A, Duan X, Yin Q, Foss CA, Fan Y, Xu Y, Li X, Cai X, Kutil Z, Wang P, Yang Z, Zhang N, Pomper MG, Wang YG*, Bařinka C*, Yang X*. A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging. Nature Communications. 2021, 12, 5460. 

7.  Wang Z, Xia H, Chen B, Wang YQ, Yin Q, Yan Y, Zhang Q, Wang YG*. pH-Amplified CRET Nanoparticles for In Vivo Imaging of Tumor Metastatic Lymph Nodes. Angewandte Chemie International Edition. 2021, 133, 14633-14641. (Hot paper)

8.  Wang YQ, Wang Z, Chen B, Yin Q, Pan M, Xia H, Zhang B, Yan Y, Jiang Z, Zhang Q, Wang YG*. Cooperative Self-Assembled Nanoparticle Induces Sequential Immunogenic Cell Death and Toll-Like Receptor Activation for Synergistic Chemo-immunotherapyNano Letters202121, 4371-4380.

9.  Yan Y, Chen B, Wang Z, Yin Q, Wang YQ, Wan F, Mo Y, Xu B, Zhang Q, Wang S*, Wang YG*. Sequential Modulations of Tumor Vasculature and Stromal Barriers Augment the Active Targeting Efficacy of Antibody-Modified Nanophotosensitizer in Desmoplastic Ovarian Carcinoma. Advanced Science. 2021, 8, 2002253. 

10. Du H, Zhao S, Wang YQ, Wang Z, Chen B, Yan Y, Yin Q, Liu D, Wan F, Zhang Q, Wang YG*. pH/Cathepsin B Hierarchical Responsive Nano-conjugates for Enhanced Tumor Penetration and Chemo-immunotherapy. Advanced Functional Materials. 2020, 30, 2003757. 

11.  Liu D, Chen BL, Mo Y, Wang Z, Qi T, Zhang Q, Wang YG*. Redox-Activated Porphyrin-Based Liposome Remote-Loaded with IDO Inhibitor for Synergistic Photoimmunotherapy through Induction of Imm​unogenic Cell Death and Blockage of IDO Pathway. Nano Letters201919, 6964-6976.  

12. Wang YG*, Wang C, Li Y, Huang G, Zhao T, Ma X, Wang Z, White MA, Sumer BD, Gao J*. Digitization of endocytic pH by hybrid ultra-pH-sensitive nanoprobes at single organelle resolution. Advanced Materials. 2017, 29, 1603794. 

13. Wang YG, Zhou KJ, Huang G, Hensley C, Huang XN, Ma XP, Zhao T, Sumer BD, DeBerardinis RJ, Gao JM*. A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Nature Materials2014, 13, 204-212. 




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Education

  • ​2005.9- 2008.7        Ph.D. in Pharmaceutics, Peking University, Beijing, China (Advisor: Prof. Qiang Zhang)
  • 2002.9- 2005.7        M.Sc. in Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China (Advisor: Prof.  Siling Wang)
  • 1998.9- 2002.7        B.Sc. in Pharmacy, Shandong University, Jinan, China